Changing Price / Cost Decimal Places Negative Impacts

Our customer has started to use discounts extensively and originally we setup 6 decimal Price / Cost because it allowed us to match to the current price structure which is specific for almost each customer. We have learned that this causes rounding issues when unit of measure conversions are introduced.  We have an opportunity when publishing the new price sheet to clean up some of this rounding by changing to a 2 decimal Price / Cost setting in Company miscellaneous settings.  In our testing this appears to correct many rounding issues.  Has anyone seen negative impacts in the transactions by reducing the number of decimals?  All input is appreaciated.